The perfect career Essay Example | Topics and Well Written Essays - 500 words

The perfect career - Essay Example Didactic approach refers to living a life which is purposeful and extensively followed by morals. There are hardly any human beings that strictly follow this great approach and this is the only reason why the world is in a chaotic state these days. A perfect career can have myriad definitions but the quest is to know the best and follow the best definition of a perfect career. A perfect career would undoubtedly be made up of several sacrifices so as to revive this forgotten word in front of the whole world. A sacrifice made is arguably the biggest contribution and this is what makes people like Mother Teresa, Nelson Mandela and others cynosures. The will and the ability to pursue the goal and a never say die attitude is what separates ordinary people from the extra ordinary people. Having a noble goal is another pivotal aspect when it comes to the perfect career, an aimless life has no significance whatsoever and there are countless people across the world that live such a kind of life. Noble aim combined with noble intensions makes the backbone of a perfect career; another pivotal factor is clarity of thought, without this even the most genius of all will not be able to capitalize on the opportunities.

Financial Reporting Assignment Example | Topics and Well Written Essays - 2250 words

Financial Reporting - Assignment Example The involvement of the all stakeholders, the identification of the economic status, financial identification and effective transmission of the components of the financial reports outlines the main characteristics of effective and good quality financial reports (Helen and Gary 2001, P. 57). Although conventional financial statement systems are still effective in providing financial reports in an organisation, the adoption of contemporary financial reporting techniques and policies have proved to be more valuable and cost-effective. Organisations provide financial reports to facilitate the successful creation of practical regulatory policies and for procurement authorisation. To address the issues of finance reporting extensively, International Trade Organisations have developed various policies aimed at harmonising the global financial reporting process for the benefit of global economic development. One such initiative was the formation of International Accounting Standards (IAS 10) to harmonise accounting practices across the globe. The main aim of the IAS 10 policy framework was to prescribe the most effective timeframe for adjusting financial statements for an organisation and to enable the identification of necessary disclosure requirements regarding the date for financial statement authorisation and the events that followed the reporting period. The standard stipulates that, an organisation should not prepare financial reports based on going-concerns. The International Accounting Standards (IAS 10) offers an explanation of the events that occur after the finance reporting date. The standard is also exceptionally decisive in explaining various activities that occur instantaneously after reporting period. Definitions Events after the reporting period- This entails the inauspicious and constructive happenings that takes place after the end of the reporting date and before the date of authorisation of the financial statement. Adjusting Events These are events that offer comprehensive evidence to support the occurrences that take place at the end of the reporting date. Adjusting events also incorporates the events that relate to the inappropriateness of the going concerns assumption in the entire or part of the financial plan (Evans, 2000, p.535). Non-Adjusting Events These are events that reveal the conditions that occur after the termination of the reporting date and do not interfere with the organisation’s financial report. These events occur at the end of the reporting period. However, these events should not be allowed to inference with the absolute finance reporting. The Scope of the Provision This standard is only appropriate in the entire accounting process, at the disclosure and in the analysis of events that occurs after the reporting time. Objective of International Accounting Standard (IAS 10) This provision is aimed at prescribing the most appropriate time for adjusting financial statements for events that might take p lace after the reporting period. The provision also offers a description of the necessary disclosures regarding the financial statement authorisation and the impact of the events that take place after the reporting date to the organisation finance report. The provision is as well expected to ensure that no organisation prepares its financial reports on a going concern basis. This occurs in the scenario where,

Functional Structure Of Skeletal Muscle

Functional Structure Of Skeletal Muscle Muscle makes up the largest group of tissues within the body, roughly half the bodys weight (Sherwood). Skeletal muscle is attached to the bones of the skeleton and through its highly developed ability contract, produces movement at joints. A controlled contraction of the muscle enables purposeful movements of the body and manipulation of objects (Sherwood). First it is important to understand the structure of the muscle and how it functions. We will then discuss the factors that control normal growth and repair in the muscle, and lastly explore how muscle atrophy results from not using a muscle. Basic structure A skeletal muscle is made up of muscle and connective tissues, which both play a role in the contracting and function of the muscle. A single cell of a skeletal muscle is called a muscle fiber, the muscle is made up of groups /bundles of these muscle fibers bound together by fibrous connective tissue, and each bundle is called a fasciculus (muscles nerves movement). Another layer of connective tissue binds the fascicule together and the whole muscle is surrounded by an outer layer of connective tissue. (M Muscle fibers Muscle fibers are long and cylindrical in shape, usually extending the whole length of a muscle. They contain multiple nuclei, which come from the fusion of smaller cells during development and formation (ezeilo and Sherwood). These nuclei lie beneath a cell membrane called the sacrolemma (ezeilo). The cytoplasm, which is known as sarcoplasm, is filled with numerous bundles of contractile proteins called myofibrils. The myofibrils contain many mitochondria, energy generating cells (ezeilo and Sherwood). Each myofibril consists of two types of myofilaments namely, the thick filaments (containing the protein myosin) and the thin filaments (containing predominantly the protein actin, but also tropinin and tropomyosin). Summary of the levels of organization in a skeletal muscle (Sherwood) Whole muscle muscle fiber myofibril thick and thin filaments myosin and actin A and I bands When viewed under a light microscope, a myofibril shows dark (the A bands) and light (the I bands) bands alternating along its length. All the bands lie parallel to each other and together lead to the muscle fibers striated appearance (ezeilo Sherwood). The thick and thin filaments are stacked in an alternating pattern which slightly overlaps each other, and this arrangement is responsible for the A and I bands (Sherwood). An A band is made up of thick filaments and the sections of thin filament that overlap on both ends of the thick filaments. The thick filaments cover the width of the A band and are only found there. There is a lighter section in the centre of the A band, where there are no thin filaments, which is called the H zone. The middle portions of the thick filaments are found in this area and a network of supporting proteins holds the thick filaments together vertically. The supporting proteins are form the M line which is found in the centre of the A band within the middle of the H zone (Sherwood). An I band consists of the section of thin filament that does not enter the A band, this means that an I band contains only thin filaments, but not the whole length of the filament (Sherwood). The Z line is the dense vertical section thats located in the centre of each I band. The portion in between two Z lines is called the sarcomere. A sarcomere is the functional unit of the muscle. A functional unit of any organ is the smallest component that can perform all the functions of that organ (Sherwood). Thus the sarcomere is the muscle fibers smallest component that can perform a contraction. The Z line forms the connection between the thin filaments of two adjacent sarcomeres. A sarcomere is made up of the entire A band and the end portion of the I band on both ends. Diagram A myofibril divided into two sarcomeres (sport-fitness-advisor.com) Cross bridges The cross bridges are the section where the thick and thin filaments overlap. The thick filaments are surrounded by the thin filaments in a hexagonal pattern. In all six direction, the cross bridges extend from the thick filaments to the surrounding thin filaments. In addition, each thin filament then has 3 thick filaments around it. The cross bridges are significant in that the binding of the actin of the thin filaments and myosin of the thick filaments happens at the cross bridges, which produces a contraction of the muscle fiber (Sherwood). Muscle contraction and cross bridges Actin and myosin are sometimes referred to as contractile proteins but neither of them actually contract during a muscle contraction. In a relaxed fiber, muscle contraction cannot take place because of the position of the proteins, tropomyosin and tropinin of the thin filament (Sherwood). Tropomysosin and tropinin are called regulatory proteins because they both play a role in stopping contraction from occurring or allowing contraction to take place by exposing the actin binding sites (Sherwood). Tropomyosin covers the sctin binding sites on the cross bridges thus blocking the interaction between myosin and actin which results in muscle contraction. Tropin is made up of 3 polypeptide units which bind to tropomyosin, actin and calcium. When troponin is not bound calcium, it stabilizes tropomyosin in the blocking of the actin sites on the cross bridges. When it is bound with calcium, the shape of the protein changes allowing tropomyosin to slide away, exposing the binding sites, and myosin and actin can bind at the cross bridges, resulting in a muscle contraction (Sherwood). Below is a diagram illustrating the position of the cross bridges, in a relaxed muscle and a contracted muscle. +, power stroke, action potential- calcium link between excitation and contraction Diagram 2: The sliding action of the cross bridges of a relaxed and contracted muscle respectively (www. teachpe.com) Adaptation of muscles to functional use One of the factors that determines the performance of a muscle is the type of muscle fibers within the muscle (N Slow fibers are known as type I fibers. These fibers are specialized in order to sustain a contraction over a longer period of time (MNM). Within these fibers there is an extensive capillary network, which allows it to be oxygen rich. The slow fibers contain myoglobin which carries oxygen, and the fiber is thus red in colour. Energy for contraction is obtained mainly from oxidative reactions. These fibers make use of a slow twitch in response to stimulation and are thus resistant to fatigue. The slow fibers contain numerous mitochrondria which, because of the rich oxygen and blood supplies, can contribute more ATP during contraction. (MARTINI chp10). Fast fibers are known as type II fibers. These fibers contain no myoglobin and are white in colour (MNM). These fibers are larger in diameter than the slow fibers and contain densely packed myofibrils, significant glycogen supplies and fewer mitochondria than slow fibers. The fast fibers use glycogen to obtain energy for contraction. They make use of a fast twitch and produce a powerful contraction; however they fatigue rapidly (MARTINI chp10). The fast fibers use large amounts of ATP during contraction and thus extended activity is supplemented by anaerobic metabolism. Skeletal muscle is able to adapt its structure depending on the functional demands required over time (MNM). The quantity of sarcomeres within the myofibrils and the proportions of fast and slow fibers can adapt and change over a period of time. Depending on what is required of a muscle over a period of time, the fibers can adapt. In training for endurance, some of the fast fibers will adapt and become similar slow fibers and function more like them. During strength/resistance training, muscle bulk and strength is increased through increase in number and size of the myofibrils mainly within the fast fibers. In addition, when a muscle is held in a shortened length over a period of time the number of sarcomeres reduces, whereas if its held in a lengthened position the number increases. This is an adaptation to the length of a muscle that helps from a functional perspective (MNM). Muscle growth and repair Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which depending on the condition, can promote muscle growth or loss (signaling atrophy and hypertrophy). The processes of protein synthesis and degradation are controlled by pathways that are affected by factors such as physical activity, mechanical loading, supply of nutrients and growth factors (signaling atrophy and hypertrophy. Muscle growth Protein turnover and cell turnover are the two processes that play a large role in the growth of skeletal muscle mass. In an embryo, cell turnover is the process which plays the predominant role in muscle growth and development. During postnatal growth, the satellite cells (stem cells) are included into the growing fibers and at the same time protein synthesis increases (atrophy hypertrophy sherwood). These satellite cells are significant in keeping the quantity of cytoplasm as well as the quantity of nuclei in the cytoplasm stable. In adults, there is significantly less cellular turnover. An increase in muscle growth is done principally through amplified protein synthesis as well as a reduction in protein breakdown (atrophy hypertrophy). GH IGF1 -AKT ++ size fibers contractile proteins into myofibrils ++diameter microtears Muscle repair When a skeletal muscle is injured, it is necessary for specific cellular pathways to be activated in order to repair the injured tissue. Serrano and Munoz-Canoves stated that activation and restriction of these pathways must be temporarily coordinated in a precise sequence as regeneration progresses if muscle integrity and homeostasis are to be restored (Regulation and dysregulation). After a skeletal muscle has been injured, a series of events happens concurrently to repair the muscle, these are initiated by the release of growth factors and cytokines from the damaged blood vessels and the penetrating inflammatory cells (Regulation and dysregulation). The initial phase of muscle regeneration is distinguished by necrosis of the injured tissue and the activation of the inflammatory response (cellular and molecular regeneration). The inflammatory cells that are released phagocytose the cell debris that is present following an injury. The encouragement of the survival of various cell types, as well as the migration and proliferation of cells, is the role of the cytokines. Following this, there is a phase of regeneration, where there is the activation of myogenic cells which multiply, differentiate and finally fuse together resulting in the formation of new myofibers, as well as the reconstruction of the functional contractile components (cellular and molecular regeneration).. The satellite cells (stem cells) play a key role in this procedure. The satellite cells make use of the necrotic basement membrane as building blocks to guide the new fibers in forming the same pattern and ensuring that they lie in similar positions. The myoblasts fuse to each other as well as the damaged myofiber and thus form the new myofiber. At the same time as this, matrix metalloproteases (MMPs) are at work. MMPs play a regulatory role with concerns to the extra cellular matrix formation, break down and remodeling (Role of MMP). The MMPs break down the necrotic base membrane components, which allows the satellite cells to migrate and differentiate in the area. In addition, angiogenesis is required to form a new vascular network within the injured muscle (regulation and dysregulation). The final stage of the muscle repair is when growth and maturation of the new muscle fiber takes place. If any of these stages persist for longer than is necessary, the result may be unsuccessful muscle repair. Unsuccessful muscle repair is characterized by continued myofiber break down, inflammation and fibrosis, ultimately, extreme build up of the extra cellular matrix components (regulation and dysregulation). Elaborate? Muscle atrophy Atrophy was defined by Macro Sandri as a decrease in cell size mainly caused by loss of organelles, cytoplasm and proteins. (signaling in atrophy and dystrophy). If a muscle is immobilsed and not used for a period of time, the amount of actin and myosin within the skeletal muscle decreases, the muscle fibers decrease in size and the muscles mass reduces, along with the muscles strength (Sherwood).

It Should NOT be a Crime to Smoke :: essays research papers

It Should NOT be a Crime to Smoke Out in the cold, a lone member of society stands alienated from the rest of the world. A plume of smoke rises from her mouth; this is what sets her apart from the rest of the population, the fact that she smokes. In the last decade, this has been happening as people become staunchly more politically correct. It has almost become a crime to smoke in this country as the year’s progress. Is this right? Should smokers be treated this way, are they worse than the rest of society just because of their habit?   Ã‚  Ã‚  Ã‚  Ã‚  Smokers have been banned from almost ever facility in this nation, save some fast food restaurants and bars. Almost all the nice restaurants have eliminated smoking sections, and for what reason: to quell the cry of all the nonsmokers in this world? If these people had their way all the smokers would be crammed into a rocket and shot off to farthest reaches of the universe. Why have smokers been driven out of public places when there are efficient ways of eliminating secondhand smoke? There are machines called smoke eaters that have been scientifically proven to eliminate 98% of the toxins found in secondhand smoke. Why are these overlooked when legislation is passed making it illegal to have smoking sections in public buildings? I do not have the answers to these questions, only the politicians do.   Ã‚  Ã‚  Ã‚  Ã‚  Ithaca College is not above these ridiculous laws. Ithaca College is trying to pass legislation that bans smoking from certain out door areas of the campus. How ridiculous is this. Smokers are not only banned from all indoor areas but now we are confined to certain outdoor areas. President Peggy Williams wants this to go through and says it is time to make a stand. I say that all the smokers of this nation should ban together and put an end to this tyranny that makes our lives more difficult every year. We must stop them from discriminating against us.   Ã‚  Ã‚  Ã‚  Ã‚  I believe that smokers should have the right to smoke anywhere outdoors and in certain areas indoors where efficient second hand smoke elimination procedures are in place. I need no backing for the outdoors claim because if smokers are not permitted to smoke outdoors than where are they allowed to smoke, only in their houses with the windows closed and the blinds drawn?

Learning Team Reflection Week Essay

The week prior we reflected on how to succeed at team building, conflict in the team work, different tip on team collaborations, and conflict skills that make a difference in the work place and in your team. As we all collaborated on our issues and thoughts about how these are used in our work place these issues different issues began show to also show up as we work together as a group complete or different assignment, the different conflict that we all face, how we work together to work those differences out and how we can overcome those optical and the roles that each of us play or even take to make sure that we are getting the job done. How to succeed at team building Team building is the one of the most important reason why organizations succeed or fail. One of the biggest barriers to building a successful team is the lack of investment by an organization in team development, whether that investment comes in the form of time or money. Building a thriving team is hard work and time consuming, which can pose a challenge for business leaders today as they want a return on their investment too quickly. It takes the commitment of the organization, team leadership, and team members to build winning teams without it the organization is dam to fail. When building a strong successful team focus of the six keys point that can assists in team bulding1. Develop employees on the right job, 2. Look to your leaders, 3. Assess the team, 4 Create a culture of engagement, 5. Give team what they need, 6. Establish conditions for success; with these six points can assist with a build a strong foundation a great team. CONFLICT IN WORK TEAMS Modern business etiquette has, for the most part, kept working together within a corporation very civil and relaxed. We have many different ways of relieving tension and conflict between workers, however it does still occur, even in ways which we do not immediately realize. Conflict can be something obvious and overt, such as an argument or companywide competition. However it can also be something much less obvious, an undiscussed bit of competition between two people, and one may simply wish to get a project done a few minutes before the other person, maybe they are each vying for a promotion or raise. It is very difficult to immediately spot issues like these, usually because the people involved do not ever speak of it, however as a manager, it is important to closely monitor morale and actions by the employees. It is also important to be able to spot how certain differences or changes to the work load, or new policies and events may create conflict between workers before and after it has been implemented. Tips on Team Collaboration Team collaboration can be both very helpful and successful or it can be very negative and waste each team member’s time. Often times, in team collaborations, one or two of the group members become overly dominant and when they speak their opinions or ideas the rest of the team just agrees with them and the brainstorming stage is over. Some tips to team collaboration that can assist in making the team successful is to first, before any work has been started, determine what the overall objective is. Ensure that each team member can answer the question, â€Å"Why are we here?† This will put each member on the same page. Secondly, make sure that each team members voice and opinions are heard and respected. Sometimes people are afraid to speak their ideas because they are afraid of the reaction they will receive, if there are team members that do not appear to be involved in brainstorming, the next idea is to have each member write their ideas out on a piece of paper. Once each person has written down their ideas the team leader can either verbally read each idea or write them on a white board for the team to see and review. Conflict skills that make a difference  conclusion Reference http://www.trilliumteams.com/articles/41/what-makes-teams-succeed

Internship Report on Ptcl

INTERNSHIP REPROT On FI-CO_ERP in [pic] ERP-Accounts & Finance Submitted By Faisal Rasheed Internship Report on PTCL Purpose Of Internship The purpose of this internship is to understand how the practical work is performed in a computer based ERP solution. In addition, to practically learn concepts which have been learned theoretically in education and to develop the understanding of the function performed by ERP Accounts and Finance. Scope of Internship In six weeks training span, it is difficult to understand every work flow of each Sub sections of Accounts & Finance department because of its huge volume of work.The main focus was in the FICO module including General Ledger, creation of vendors, Customers, issuance/Receiving of advance, parking of invoices, posting and payment/receipt of invoices and cheque printing, Addition in Defaulters, Bad debts Provisions, Adjustment of Provision, and Recovery from Defaulter. Constitution and ownership, Mission, Vision & Core Values Pakistan Telecommunication Company Limited (PTCL) Pakistan Telecommunication Company Limited (â€Å"the holding Company†) was incorporated in Pakistan on December 31, 1995 and commenced business on January 01, 1996. The Company is listed on Karachi, Lahore and Islamabad stock exchanges.The Company was established to undertake the telecommunication business formerly carried on by Pakistan Telecommunication Corporation (PTC). The business was transferred to the Company on January 01, 1996 under the Pakistan Telecommunication (Re-organization) Act, 1996 at which date the Company took over all the properties, rights, assets, obligations and liabilities of PTC except those transferred to National Telecommunication Corporation (NTC), Frequency Allocation Board (FAB), Pakistan Telecommunication Authority (PTA) and Pakistan Telecommunication Employees Trust (PTET).The registered office of the Company is situated at PTCL Headquarters, G-8/4, Islamabad. As a consequence of PTCL’s privati zation during 2006, 26 % of its shares were acquired by Etisalat International Pakistan LLC, based in the UAE. Pak Telecom Mobile Limited (PTML) PTML was incorporated in Pakistan on July 18, 1998, as a public limited company, to provide cellular mobile telephony services in Pakistan. PTML commenced its commercial operations on January 29, 2001, under the brand name of Ufone . It is a wholly owned subsidiary of PTCL. The registered office of PTML is situated at F-7 Markaz, Islamabad.Maskatiya Communications (Private) Limited (MAXCOM) On March 01, 2010 the holding Company acquired 100 % shares of MAXCOM. MAXCOM has been voluntarily wound up, effective June 01, 2011 based on a special resolution passed by the members of MAXCOM. The net assets of MAXCOM have been transferred to PTCL at a book value amounting to Rs 68,382 thousand and the goodwill related to acquisition of MAXCOM has been written off during the year. PTCL Corporate Vision To be the leading ICT service provider in the reg ion by achieving customers’ satisfaction and maximizing shareholders’ value. PTCL Mission To achieve our vision by having: †¢ An organizational environment that fosters †¢ professionalism, motivation and quality. †¢ An environment that is cost effective and quality †¢ conscious. †¢ Services that are based on the most optimum †¢ technology. †¢ â€Å"Quality† and â€Å"Time† conscious customer services. †¢ Sustained growth in earnings and profitability. PTCL Core Values †¢ Professional Integrity †¢ Customer Satisfaction †¢ Teamwork †¢ Company Loyalty Organizational Structure Accounts & Finance Department Related to ERP Only Under the President & C. E. O, total 9 department head Including seven S. E. V. P’s, C. T.O and C. I. O are working each one is responsible for formulating planning & strategies at corporate level with the support of their Teams. Each S. E. V. P has more than one E. V. Pà ¢â‚¬â„¢s and their teams. Under S. E. V. P Finance– C. F. O, three E. V. P’s are working related to Revenue Accounts & Revenue Assurance, Financial Planning & Treasury Management, & Accounts Services. Under the E. V. P- Accounts Services, total two General Managers including G. M Accounts Taxation & Financial Reporting, G. M ERP Finance & Assets Management are working. Each G. M has at least one Senior Manager or Manager or both. Each S.M or Manager has at least one Financial Analyst or Assistant Manager. Internees are reportable to Assistant Manager or Financial Analyst. ERP and Its Functionality ERP (enterprise resource planning) is an industry term for the broad set of activities that helps a business manage the important parts of its business. The information made available through an ERP system provides visibility for key performance indicators (KPIs) required for meeting corporate objectives. ERP software applications can be used to manage product planning, parts purchasing, inventories, interacting with suppliers, providing customer service, and tracking orders.ERP can also include application modules for the finance and human resources aspects of a business. Typically, an ERP system uses or is integrated with a relational database system. [pic] SAP – ERP Solution and its Functional Support [pic] SAP (System Application Product) R/3 is a 3 tier Real time data processing system developed by SAP AG, a German software company. The R/3 system, which is also known as ERP (Enterprise Resource Planning) System, is a tightly integrated collection of applications designed to handle the entire data processing for many different types and sizes of organizations.Within R/3 is a run time environment and a set of application programs written in ABAP/4 programming language, which are highly customizable and scalable. SAP R/3 system has a three-tier client/server architecture. The classic configuration of an R/3 system contains three software layer s, as given in the below picture. [pic] †¢ Presentation layer The PC-based GUI interface that is used by the end-user community. †¢ Application layer The SAP application servers that service requests for data and manage the interface to the presentation layer. †¢ Database layerThe actual DBMS that communicates with the application servers to fulfill their requests for data. SAP allows the IT supported processing of a multitude of tasks, accruing in a typical company or bank. SAP ERP is differing from R/3 mainly because it is based on SAP NetWeaver: core components can be implemented in ABAP and in Java and new functional areas are mostly no longer created as part of the previous ERP system, with closely interconnected constituents, but as self-contained components or even systems. SAP in PTCL Every company has its own unique business processes to meet requirement and challenges. That is why PTCL uses the SAP.SAP is standard project system it is divided into three serv ers. 1. Development Server 100 & 300 2. Quality Assurance Server 600 & 790 3. Production. Server 800 In the development Server 100 new developments are made by SEMINES/ PTCL Development Team with help on business functional Team leads, technical coding is done in this server through SPRO & ABAP Language. The ERP staff consolidates the issues of users and solves them as per requirements. ERP Team Test the development made in development Server 300. Development server data, after testing the codlings and commands, is readily available for transferring to quality server.In the SAP the quality assurance is made for learning and testing. The QAS(Quality Assurance Server) 600 or 790 is used for the trainings purposes and to familiarize the user with the system. After testing the data, based on real scenarios, in quality Server the data is ready for transferring in production from where the users use it live. Production Server 800 is the main and live part of System Application Product on which all the financial and non financial records are kept on real time basis. FICO( Financial & Controlling) Module Includes the Following FI (Financial):- †¢ General Ledger accounting †¢ Accounts payable Accounts receivable †¢ Asset accounting †¢ Travel Management CO (Controlling):- †¢ Cost element accounting †¢ Cost center accounting †¢ Internal orders †¢ Profit center accounting †¢ Profitability analysis Following Pictures will help you in understanding the SP ERP FICO Module and the related departments head functions of any organization. Process Flow: Payments & FR: Signatory Authority and Responsibility for Payment Drawing and Disbursement Office (DDO) i. e S. M of each region who is responsible for all nature of payment & recoveries related to employees, supplier and contractor as per policies and contracts made by this department.Financial Reporting DDOs in regions recognize the financial transactions in whole month and the 3 work ing day of the next month are given to each department so that they can make sure the closing of last month is completed. Accounts section in the head quarter downloads all data related to each month from the main server & prepares an unregistered trail balance for the same, and then forward it to the SM nominal ledger for finalizes the records hence the financial information with any error can be rectified immediately so that Financial Statements can made on timely basis.Monthly accounts, Quarterly, Half yearly & Yearly accounts are maintained and compared with the last year. Some estimates and provisions at year end are taken to the annual report. PTCL follow financial year from July to June Whereas ETISALAT follow calendar year as Financial Year. ERP SAP Assignment I was given internship with GM ERP-Finance whereas I had worked with Manager ERP-Finance and Financial Analyst D. B & I. S. They taught me many concept of SYSTEM APPLICTION PRODUCT (SAP) – FICO, & I am very than kful to both of them.Following are the major activities performed by Financial Analyst in Accounts Payable; a part of FICO Module in SAP. Vendor Master Record: †¢ Create/Change/ Display/ Block or Unblock Vendor Master Data (T CODE FK01, FK02, FK03,FK05): Type FK01 in command Line and press enter; here you will be asked for the fields of vendors to be filled like Company Code, Vendor Group, Title Mr. Mrs. M/S etc, Name, street address, Postal Code, Telephone, VAT Reg No, Vendor Bank Details, Sort Key, Payment Terms, and Payment Method. For the display use FK02 and if any changes in any field of vendor required use FK03.If you want to block or unblock any Vendor use FK05. See below how to do the above task manually means without using TCODES, by using SAP Menu. †¢ Parking of vender invoice (TCODE FV60, F-63) Credit Memo(TCODE FV65): Parking saves the data in the form of batches, here the entry is saved but without updating the related ledge. Posting is required for updating GL Balances. You can park invoices or credit memos which mean that you enter the invoice data or credit memo data in the system and save it in a document, but the system does not post this invoice initially.You can change a parked document as often as you wish, for example, by adding or correcting data. The changes are logged. When you have finished changing the document, you can post the parked document. Only when you post an invoice or credit memo, does the system carry out the normal account movements and make the necessary updates. Why we Need of Parking? Document Parking by One Accounts Payable Clerk An employee is interrupted when entering an invoice. He or she can park the document and continue processing it later on. This saves him or her having to enter the data twice.OR An employee wants to clarify certain issues before posting an invoice. He or she can park the document and continue processing it later on. This saves him or her having to enter the data twice. The process flow is organized in such a way that one employee parks invoices without checking them. Another employee then performs invoice verification and posts the parked documents, possibly after changing them. OR The process flow is organized in such a way that one employee saves invoices as complete for posting, this means that the balance is zero and no more changes are necessary.Another employee then approves these invoice documents, if they are subject to release. †¢ Posting of vender invoice/ Credit Memo or Changing in Parked Invoice (for TCODE See Picture): If you are directly posting an invoice/ credit memo then choose Document Entry 1st highlighted menu, otherwise to post the parked documents choose Parked document. Any changes in the post or parked document shall be dealt from the 2nd highlighted menu. †¢ Outgoing Payment or Down Payment or Print Cheques (for TCODE See Picture): Outgoing Payment means payment against the booked invoice which is dealt with the 1st highligh ted menu.On the other hand, Down Payment means the Payment before the Invoice creation which is dealt through 2nd highlighted menu and the clearing of the same will also be dealt from this menu. In the both transaction you Debit the Vendor Account and Credit the Bank. Only difference is the Special GL indicator â€Å"a† which is used for down payment. As per PTCL / PTML policy no advance has been given to any Vendor without PO (approved) so this field is mandatory. Another interesting thing, payments are made by the Cheques (see highlighted 2nd & 3rd menu). To print Cheques following steps are required.When a vendor invoice is parked document containing 25000xxx is generated. Next step is to post the invoice by a senior manager (as signatory authority) which generates document no. 26000xxx. Now Cheque is available for printing. Time barred Cheque is a type represents those Cheques which are not presented within six months, these will be reversed by the S. M. †¢ REPORTING : Display Balances, Display/Change Line Items, Clearing except Down Payment (for TCODE See Picture): From highlighted menu you can view the balances or you can change any line item or you can clear invoices, reversals, credit memos, outgoing Payment.However, Down payment partial clearing should be done from the down payment menu as mentioned in the previous page TCODE F-54. Clearing a vendor document means nothing is outstanding for the document; the document is completed in all respect. [pic] SAP Include many modules which are integrated with each other in such a way that output of one module can be used as input for another or the same module. The following Landscape Picture represents the all SAP modules functionality & its practical application. Almost all of the modules are purchased by PTCL and working. Other Task other than ERP SAPSM Data Base Account coordinates with different integrated modules of system SAP i. e. FI, CO, HCM &MM. SM Data Base Account is directly reportable to the GM Accounts for any problem regarding working in SAP and also reportable to gm ERP Finance regarding FICO Role assignment. Following are the some responsibilities of Financial Analyst Data Base Account on which I have worked. Account Payable (Create, Block, And Unblock Vender) Non PO Based Vendors are created in SAP by a financial analyst Accounts & database. From time to time these vendors are blocked due to some reasons e. g.Vendor regularly not in use, block for payment or block for business. However, whenever any blocked vendor is needed it can be activated/ unblocked. Account Receiveable (Create, block, and unblock customer) Customers are also created in the account data base department. These customers can be blocked, unblock at any time as per the requirement of the user. Fico Role Assignment New employee is assigned to work on SAP FICO Module; user role assignment for quality server 90 is made by financial analyst Accounts & database. This form includes the TCODES he or she is going to use on SAP.GM ERP Finance, SM Accounts Database, GM ERP Teams, and new user must sign Role Assignment Document. After this step, ERP team creates new user on QAS (Quality Assurance Server). Once the user is familiar with the TCODES and its working on Quality he or she can apply for the Production Server 800 which is also dealt from this office. Liaison with Finance, Accounts and ERP An interesting task which is also performed here is to convey the problem of the FICO end users to the ERP Team on timely basis so that solution can be immediately available for the user who can then work efficiently.Other Tasks To make each month a report of the users who are using TCODES which are not assigned any more to them and with the help of ERP Team withdraw these roles from their users as per authority matrix. To make sure all the GL, Vendor, Customers, Commitment items are also available in QAS 790 if compared with Production Server 800. MS Outlook is also used all over the departments and is becoming very powerful tool to convey massages on timely basis. This office receives emails for Vendors and Customers creation, blocking and unblocking. Special Terms used in SAP:I had gone through many TCODES in SAP which were the part of FICO; it is not difficult to grip on SAP in this 6 weeks training if you are familiar with these terminologies given below you can easily understand how SAP works. Commitment Item: These account numbers are basically used for the allocation of budgets. Relationship of CI to GL is one to many which means One CI can cover more than one GL. e. g. there are so many Maintenance GL, however only one commitment item for these GL’s can be choose for budget allocation. Sort Key: It indicates the layout rule for the Allocation field in the document line item.Assignment Field: Assignment Field is a part of Line Item Display. The system notes the line items that have been posted to each customer account. You can display the line ite ms on the line item display screen. You can specify the sort sequence of the line items by entering a key in the Sort key field in the account master record. This key specifies how the Assignment field is to be filled in the line items that are posted to the customer account. When you call up the line item display, the system sorts the line items according to the contents of this field.You can change the sort sequence in the line item display. e. g. 002 is the sort key when you make Customer or Vendor for NON PO BASED in PTCL company code 1100. 002 sort key is configured to display the document number with fiscal year as assignment field. Special GL Indicator: For all line items in customer or vendor accounts which are updated to an alternative reconciliation account in the general ledger, the special G/L indicator determines which account is to be selected e. g. â€Å"A† is used for down payment of Vendors; â€Å"M† is used for defaulters of Accounts Receivable.Accoun t Type: Key that specifies the accounting area to which an account belongs like asset accounts, customer accounts, vendor accounts, G/L accounts etc. The account type is required in addition to the account number in order to identify an account, since the same account number can be used for each account type . e. g. â€Å"K† for Vendors, â€Å"D† for Customer Document Type: It classifies the accounting documents. It is stored in the document header. Attributes that control the entry of the document, or which are themselves noted in the document, are defined for each document type.Like â€Å"KA† is a vendor document. Posting key specifies the nature of account (e. g. GL account, Customer account, Vendor account etc. ) and controls the debit / credit indicator of the amount e. g. â€Å"40† is used for GL Debit â€Å"50† is used for GL credits Stimulation: means overview of accounting document after: o Execution of all Substitutions o Execution of all validations o Creation of automatically created line Items Profit Center: A profit center is a management-oriented organizational unit used for internal controlling purposes.Dividing your company up into profit centers allows you to analyze areas of responsibility and to delegate responsibility to decentralized units, thus treating them as â€Å"companies within the company†. Cost Center: An organizational unit within a controlling area that represents a defined location of cost incurrence. Its a part of a company seen as a separate area of responsibility, location or cost-accounting entity. Place at which costs occur. Company Code: The company code is an organizational unit within financial accounting, e. g. 1100 for PTCL & 1300 for UFONE (PTML).Account Group: The Account Group to which your vendor/ Customer/ Employee will belongs to. Control key in the Bank Details: Represent nature of account (i. e. Current a/c, Saving a/c, etc. ) Withholding Tax Type: This indicator is u sed to classify the different types of withholding tax eg. â€Å"Z2† is used payment for supply of Goods; â€Å"Z3† is used for contractors; â€Å"Z4† is used for payment of services W/tax Code: Codes determine is the various percentage rates for the withholding tax type. Liable: If you set this indicator, you tell the system that the vendor is subject to withholding tax for this withholding tax type.If the involved party vendor or employee is exempted from withholding tax so provide details of exemption. e. g. 3. 5%, 6% etc Reference Document Number: The reference document number can contain the document number of the business partner, but a different entry can also be made. The reference document number can be used as search criteria for document display/change. Period: Account transaction figures are updated per period within the fiscal year . A maximum of 16 periods can be updated. You define how a fiscal year is divided into periods per company code e. g. p eriod means March and 1 period means July. Document Header Text: This text contains explanations or notes which apply to the document as a whole, that is, not only for certain line items. Findings and Recommendations in Processes †¢ In PTCL there is a room for improvement. Besides, this is one of the best organization w. r. t. its environment, culture and SOP’s. †¢ In my opinion, meetings with the lower staff should also be done at least once in a month in a friendly manner. Managers, Senior Managers, & General Manager should ask their working problems in their respective epartment and should also ask for the solutions. †¢ E mail in PTCL taken the place of meetings. In my point of view, email of an officer should be considered as authentic proof for getting required authorization for any task. †¢ Coordination and Communication between departments are excellent. †¢ One department must support another department irrespective of their own interest. Organ ization Interest must be the first priority while working. †¢ I believe that Job rotations should be done to improve skills of employees in all related departments. I found employees are very loyal and dedicated towards their assigned work. †¢ Extracurricular activities arrange by PTCL like Painting Exhibition is another good and relaxing activity for employees and their families. In my opinion, such occasion must be held at least once a year. SPECIAL THANKS I am indebted and thankful to the PTCL which gave me a chance to learn about the business processes of accounts and finance wing and also thankful to the staff especially to the Manager ERP Finance and Financial Analyst D.B & I. S under whom I was attached with. They are all professional and cooperative and guided me that how to work in a professional environment. [pic][pic][pic] ———————– S. E. V. P Finance/ CFO President / Vice President E. V. P Account Services G. M Accounts G. M ERP Finance S. M Accounts D. B & I. S Financial Analyst ERP Accounts Financial Analyst D. B & I. S Manager ERP Finance Accounts ———————– 21

Aircraft Warfare in WWI

Aircraft Warfare in WWI During the first World War,  the industrialization of the aircraft industry became entrenched as a vital piece of the modern war machine. Although it was just shy of two decades after the first airplane  was flown in the United States in 1903, by the time the WWI broke out, the military already had plans for these new means of warfare. In the years leading up to World War One, military aviation was sponsored by powerful people in government and business, and by 1909 both France and Germany had military air branches with a focus on reconnaissance and bombing. During the war, the belligerents quickly took to the air to gain an advantage. Pilots were initially sent up on missions to photograph enemy bases and troop movements so war strategists could plan their next moves, but as pilots began shooting at one another, the idea of aerial combat emerged as a new means of warfare that would someday evolve into the drone-strike technology we have today. The Invention of Aerial Combat The biggest leap forward in early aerial combat came when Frenchman Roland Garros attached a machine gun to his plane, making an attempt to synchronize with the propeller and use metal bands to deflect bullets from this vital piece of machinery. After a brief period of aerial dominance, Garros crashed and the Germans were able to study his craft. Dutchman Anthony Fokker, who was working for the Germans, then created interrupter gear to allow a machine gun to be safely shot and miss the propeller. Fierce aerial combat with dedicated fighter planes then followed. The cult of the air ace and their tally of kills was close behind; it was used by British, French, and German media to inspire their nations and none were more famous than Manfred von Richthofen, better known as the Red Baron  because of the color of his plane. Plane technology, pilot training, and aerial combat techniques all developed rapidly during the first parts of World War One, with advantage switching back and forth with each new development. Battle formation developed by around 1918, when there could be more than a hundred planes all working on the same attack plan. The Effects of the War Training was just as deadly as flying; over half of the Royal Flying Corps casualties occurred in training and, as a result, the air arm had become a recognized and highly distinguished part of the military. However, neither side ever achieved total air superiority for very long though the Germans briefly managed to cover their small base at  Verdun  in 1916 with a dominant air cover. By 1918, aerial warfare had become so important that there were thousands of planes crewed and supported by hundreds of thousands of people, all produced by a massive industry. Despite the belief- then and now- that this war was fought by individuals daring to fly for either side, aerial warfare was really one of attrition instead of victory. The effect of aircraft on the outcome of the war was indirect. They didn’t achieve victories but were invaluable in supporting infantry and artillery. Despite the evidence to the contrary, people left the war assuming that the aerial bombardment of civilians could destroy morale and end a war sooner. The German bombing of Britain- via zeppelin in 1915- failed to have any effect and the war continued anyway. Still, this belief persisted into WWII where both sides terror-bombed civilians in order to try to force a surrender.

12 Rules for Punctuating Dialogue Like a BOSS

12 Rules for Punctuating Dialogue Like a BOSS How to Punctuate Dialogue: A Guide for Writers Do you use single or double quote marks for dialogue? Find out here. The rules of punctuating dialogue, whether in fiction or non-fiction, are tricksy little creatures. Despite our exposure to hundreds of thousands of dialogue lines, writers aren’t always familiar with how to punctuate a scene where characters are speaking to each other. But this, of course, is by design.With well-written dialogue,  readers shouldn’t notice the periods and quote marks. Their function is to make the words easier to read and disappear into the background. In this post, we’ll take you through the basics of how to punctuate dialogue. By the end, you can be sure that your dialogue never trips over its own commas ever again. Rule #1: Should you use double or single quotation marks?In American English, direct speech is normally represented with double quotation marks:â€Å"It’s time to pay the piper.†You might see British editors occasionally place a period (or full stop, as they say) outside the quote marks. But in those cases, it is not used for spoken dialogue but for quoting "sentence fragments", or perhaps when styling the title of a short story like "The Gift of the Magi". If you have any thoughts or questions, leave a message in the comments below.

485 Forensic Law Midterm Exam

The most important fact that makes forensic evidence circumstantial is because science cannot be clearly defined by law. The legal system have created standards and written legal rules regarding the admissibility of forensic evidence. When forensic evidence that is presented in court is rarely unaccompanied by an expert witness to provide the court room with a professional explanation backing the reliability of the forensic process used to collect the relevant evidence. This is one the major obstacles in the modern courtroom. Expert witnesses are intended to provide the court with a detailed description of the forensic evidence being presented and how that evidence was analyzed through the use of forensic science. This makes an expert witness’s testimony a testimony to probability and circumstance, rather than actual fact. Consequently, the forensic evidence that is presented is ruled as circumstantial. The primary reason that science cannot be clearly defined by law is the rate of change and new theory that occurs regularly in science. There have been numerous cases where scientific evidence is found to be incorrect or inconclusive when it is admitted into evidence. This is a major concern for the courtroom as false convictions are detrimental to the integrity of the judicial system. Admissible forensic evidence is most always considered circumstantial so that there must be other forms of evidence to support the conclusion made from the forensic evidence to make a ruling. 2. Explain ways in which an opposing attorney can challenge an expert’s testimony in court. The primary goal of an attorney during cross examination is to destroy the credibility of a witness’s testimony. Expert witnesses are held to a different standard during trial and are considered professional witnesses as they speak on the behalf of a professional opinion and understanding of the information being presented; rather than the account or an experience. Regardless of who they witness is, it is important the Federal Rules of Evidence are upheld during cross examination. There are multiple rules against the presentation of past history of witness and attack of their personal character. That being said, an attorney may reference background and qualifications of an expert witness disprove the creditably of the witness as a professional in the field they are giving testimony to. An attorney may do this by researching the expert or the field that they practice and present them question that may cause they to refute their previous testimony or have no answer to a question. Causing an expert witness to look confused or untruthful on the stand shows the jury that jury that their testimony may not be credible or the judge has the authority to dismiss the witness completely. Another approach that is commonly executed during cross examination by an attorney is challenging of the validity and probativity of the expert witnesses testimony. Attorneys may focus on the limitations of the testimony and attempt to show the jury that the testimony is insignificant and inconclusive to show any benefit in proving or disproving any evidence or a fact at trial. An attorney may also challenge the purpose of the testimony. If the attorney can ask questions that show the testimony is insignificant and is not being used to prove or disprove evidence. Then the attorney may be able to have the judge dismiss the testimony. 3. Explain exactly what makes a witness an expert witness and provide an example of a specific forensic science expert witness. Also, explain what scientific expert opinion is and what is required before a court will allow this type of special testimony. An expert witness is considered an expert according to their credentials in the professional field that they are testifying in accordance with. Expert witnesses are used by attorneys to give professional opinion and explanation of information that the common individual would otherwise have no understanding of. Searching the web I discovered SEAK a website devoted to compiling information on expert witness. All of the expert witnesses listed on the site have been previously used in cases to provide testimony to specific evidence that is within the parameters of their expertise and professional credentials. Jill Kessler Miller is a great example of a specific expert witness. Jill resides in Southern California and is an expert in forensic science and dogs. She has testified in nine trials over the past four years. She has had over twenty-five years of experience with training dogs. She has a college degree in English and a graduate certification in Animal Policy Advocacy. The site also lists the multiple specific topics she gives testimony to. This is a great example of an expert witness because she lists are her professional credentials and specific fields that she will testify about in court. Dog bites and veterinary forensics are her direct links to forensic evidence. An expert witness’s expertise, training and special knowledge of a subject allows them to be give opinion is court. There is an exception to the rule against witnesses presenting anything but fact. Regardless, an expert witness’s opinion must be unbiased and bases solely on their special knowledge, train, and expertise in the field. The opposing attorney also has the right to confrontation to this opinion. 4. Explain in general how forensic evidence and analysis of this evidence can aid investigators in determining what took place at a crime scene. How would this information be helpful to an investigation? There are multiple different disciplines of forensic evidence and each different of discipline of forensic evidence can assist investigators to analysis specific evidence to identify its significance in the investigation. When a crime occurs an investigator arrive at the scene of the crime there first set it collect and document all the evidence found at the scene of the crime that looks like it make be out of place or help draw connections to the culprits of the crime. If hair, fibers, fingerprints, tire tracks, bite marks, etc. are found at a crime scene those materials or makes are correct and examined through the use of forensic evidence. The goal of forensic evidence is to analysis the materials collected and draw connections through science to link specific individuals or objects to the crime scene by matching the scientific components. This information is helpful to an investigator because it can provide time estimates of when the crime occurred, if the crime occurred at the location, who may be involved, what may have been used to commit the crime, etc. , but overall what caused the crime to occur. 5. Identify ten separate areas of forensic science that would commonly be utilized at a crime scene investigation and give a brief explanation of each. Hair analysis is the examination of human or animal hair. Forensic science is able to distinguish the difference between the two. Depending on the sample and if the follicle is still attached, science can recover DNA from the hair. Difference can also be made between what area of the body hair originated from. Fiber analysis is the examination of man-made fibers. Forensic science is able to identify through different processes the origination object a fiber may have come from and also may be able to identify what action cause the final location of the fiber. Fiber location can be a good indicator of a struggle or specific actions during a crime. Tread analysis is the examination of treads or tire marks. Upon discovery treads or tire marks are photographed and sometimes casted for examination. These photographs or casts are analyzed to determine the type of vehicle the treads could have come from. Ballistic analysis is the examination or firearms and ammunition. When cases involve firearms and ammunition, ballistic science is used to identify the characteristics of the ammunition discovered and link it to the type of firearm or exact firearm through the identification or rifling in the barrel or the firearm. Glass analysis is the examination of glass. Forensic science can examine glass to identify its refractive characteristics or composition to connect it to other samples of glass collected. There are numerous types of glass and forensic science is able to assist in identifying and matching samples. Paint analysis is the examination of paint samples. Forensic science is used to link paint samples recovered and link those samples to a source of origin. Paint analysis is common to link vehicles and weapons to a crime. Soil analysis is the examination or soil particles. Forensic science can identify even minute traces of soil particles and identify its characteristics, possibly origin. Footprint analysis examines the foot or shoe impressions. Forensic science can indicate through photographs or castings the size of foot, if it is human or animal in origin, if the speed of the individual, type of shoe the individual was wearing. Fingerprint analysis examines human fingerprints. Each individual person has different fingerprints and forensic science can examine one fingerprint and link it to a specific individual. Blood spatter analysis is the examination of blood and how it arrived at its discovered location. Forensic science can analysis blood spatter to indicate the origin of the blood and what may have taken place in what direction and matter to cause the specific patterns of blood discovered. 6. What can a forensic scientist/expert ascertain from hair samples located at a crime scene or on a victim? What would the expert be able to testify to upon analysis of these samples? Hair evidence is commonly discovered at the crime scene because both humans and animal are always shedding hair. The important job or hair forensic analysis is to discover the origins of the sample collected. If a hair sample still have a follicle attach it is possible for a forensic scientist is acquire a DNA pattern from the hair. The characteristics of a hair sample will also indicated the type of hair and location of the body where the hair would have originated from. Examination of the hair root can indicate whether the hair was removed through force or naturally shed by the body. At trial the expert may testify to the all the characteristics able that are possible to discover through a hair sample. Also, an expert may testify to the location of hair and how the characteristics of the hair sample may indicate a certain type of behavior for that hair to be found in the location it was. For example, if a male pubic hair is found in the location or a female genital area then that may be an indication of sexually deviancy. All of this testimony would be circumstantial and only a presentation of possible reasoning for hair characteristics and location. 7. How was fiber evidence utilized to convict Wayne Williams in the Atlanta Child Killing murders? Williams was convicted using seven different fiber and hair associations to the victim Jimmy Ray Payne. Payne was found in a river, but his cloths still retained fibers that were left on the body from his contact with Williams. The medical examiner was able to recover these fibers and sent them in for forensic testing. Through forensic testing it was found that two different fiber strands were consistent with the characteristics of Williams’ bed spread and bedroom carpet. Other fibers retrieved from Payne were consistent with William’s car. Other fibers where connected to various fibers throughout Williams’ home. Once the fibers were from Payne were linked to Williams, the FBI examined the fiber evidence from eleven other victims and through consistencies between all the fibers that were collected where able to link Williams is some way to all twelve murders through the fibers evidence. 8. How can certain marks located on a bullet be analyzed and used to help determine the exact gun from which the bullet was fired? Each individual firearm is created baring its own rifling. Rifling is the groves located within the barrel of a gun that assist the bullet to spin while exiting the gun and pierce through the air without wavering or tumbling. The rifling of the gun leaves distinct marks on the bullets that allow the bullet to be traces the specific rifling of the gun that shot the bullet. If there is no gun present to be directly compared to the bullet, rifling can also being used to identify the specific caliber or mark of the firearm used to fire the bullet. 9. How could glass or paint evidence be used to help solve a hit-and-run motor vehicle accident? What would the forensic expert be able to testify to when comparing glass or paint located at the scene in order to trace paint or glass evidence located on a suspect’s vehicle? Paint and glass evidence can be crucial in linking suspects and vehicles used in hit-and-run crimes. In most hit and run cases, when a vehicle strikes an individual or object traces of paint and glass may be transferred from the vehicle to the individual or object that was struck. Paint evidence is limited to the size or the sample and amount of paint transferred during contact. If the paint characteristics are identified, then those characteristics can be used to link the sample to the type or paint and color. If paint and color can be found and glass samples are left at the scene of a hit and run it is likely that the type of vehicle can be identified. Different types make, models, and types of vehicles utilize different types of glass in the construction of the vehicle. Glass forensic evidence can use glass sample taken from the scene to identify the type of glass and compare it to other samples to indicate possible origins of the sample. An expert witness cannot directly implicate a suspect in a crime by the glass or paint evidence from the scene of the crime and sample taken from the suspect vehicle. However, the expert witness can testify that the samples from the suspect’s car and the evidence collected from the scene have the sample characteristics. Also, an expert may be able to show that the damage or striations found at the scene could indicate that the car’s damage could have been directly caused by striking the individual or object involved in the hit-and-run.

Dimensions Essay Example | Topics and Well Written Essays - 250 words

Dimensions - Essay Example Furthermore, he categorizes people as monochromic or polychromic people. Monochromic people denote individuals who do one thing before another and are often not easily distractible when doing something. In addition, they are committed to work and respect deadlines. Polychromic people Finally, Hall talks about proxemics in the cultural dimensions. He insists that there exists a public space, personal space, social space, and intimate space which everyone has to aware and watch them so that one can know when to and when not to intrude ones space. Choose one or more of the cultural dimensions discussed in this week’s lecture and your reading so far (i.e., Hall, Hofstede, Trompenaars, House, Schwartz, etc.), and reflect on where you think you would place on that dimension’s continuum, and how that might impact your behaviour and attitudes working in a multicultural team where some members are quite different on that

UK business school Research Proposal Example | Topics and Well Written Essays - 750 words

UK business school - Research Proposal Example The availability of resources that are pre-requisite for the setting up of a business institution; the most important factor being the availability and the quality of the instructors that are present to teach at these institutions. The most critical factor amongst many for the business institutions is the great emphasis on quality. Most organizations are dwindled in their quest for excellence in the face of increasing consumer base which leads to greater revenues; therefore, to be focused on the emphasis on quality is certainly a great factor contributing to the success of these institutions as they have been able to successfully prevent applying trade-offs that are detrimental to the level of quality of the institution, which has in turn helped them maintain a level of quality; favorable effects of which have been experienced throughout the institution. Other success factors are favorable external conditions such helpful government policies, peaceful communal conditions etc; all of which conspire together to provide a supportive base for these institutions. ... the face of increasing consumer base which leads to greater revenues; therefore, to be focused on the emphasis on quality is certainly a great factor contributing to the success of these institutions as they have been able to successfully prevent applying trade-offs that are detrimental to the level of quality of the institution, which has in turn helped them maintain a level of quality; favorable effects of which have been experienced throughout the institution. Other success factors are favorable external conditions such helpful government policies, peaceful communal conditions etc; all of which conspire together to provide a supportive base for these institutions. (RAPIDBI, 2008) These success factors are likely to remain in the future as the emphasis on quality is an ingredient of success which is not contingent upon time; it remains a critical success factor at any point in time. In addition, the conditions in the UK can be expected to remain stable in the future so we can expec t no new occurrence of negative externalities to arise in the future. The Norwich Business School certainly holds a significant position in the industry of UK business institutions and that is largely due to rich educational experience that is promulgated by the institutions and the wide range of degrees that offered that in this business institution. With 600 undergraduate students and 180 post graduate students and operating in the Social Sciences market place, one can see that The Norwich Business School is certainly a big player in its specific market and, hence, it must be given due credit as being a major player with regards to the current market place. In addition, the future outlook of the organization looks fine as the university is multi-disciplinary and also has a School of

Salvador Dali - The Persistence of Memory Essay Example | Topics and Well Written Essays - 500 words

Salvador Dali - The Persistence of Memory - Essay Example The essay "Salvador Dali - The Persistence of Memory" discovers the artwork of the famous painter, Salvador Dali. While this might seem uncanny enough, the clocks are not flat as you might expect them to be, but are bent out of shape, appearing to be in the act of melting away. The melting aspect can be explained that the region in which they are located is a desert climatic zone which is marked by extremely high temperatures. This weird and unexpected juxtaposition poses a lot of questions right up-front. First and foremost one has to wonder why the clocks are melting or question their location in the desert. The finally question to ponder is the fact that there are no people around them. Since the subject matter and content of the Salvador Dali's clocks painting seems illogical or irrational, one might be surprised by the very representational and nearly photographic quality of the painting, fitting well with Dali's own description of his art as being hand-painted dream photographs . The concept of the dream in this case is integral in understanding Surrealism and plays a key role in the meaning of The Persistence of Memory, as well. One of the goals of the Surrealists was to bring out the best visual representation of what it is like to be dreaming. As a result of this, Surrealism might seem a little crazy but every individual has had a case of dreams where unrelated people, places, or objects come together in completely inexplicable ways. The understanding most likely depicts a dream state.

Rhetorical Analysis of JFK'S Inaugural Address Essay

Rhetorical Analysis of JFK'S Inaugural Address - Essay Example Therefore, the speech encourages Americans that through him a torch of a new revolution has been handed over to them and all must participate. JFK feels that in unity Americans can achieve more. Therefore, he calls them to a pledge of allegiance to the nation. Additionally, JKF called for Americans to be proud of their nation and to give it the necessary support to climb ladders that other nations have not climbed. His speech lures Americans to believe in their great potential to bring about changes they want in their land and beyond. This paper will focus on rhetorical analysis of JFK’s inaugural address. The inaugural speech by JFK had several goals. First, JFK needed to pass a message of accomplishment in winning the presidential elections. Kennedy was nominated as the democratic candidate for presidency in 1960, defeating the republican’s choice, Richard Nixon. Therefore, JFK starts his speech with diction to show his celebration of winning and his belief in freedom gained through his election. To him, this day not only signifies victory but also is a celebration of freedom, because it symbolizes the end of poor leadership and a beginning of another era. JFK starts his speech by reminding Americans of the pre-existing sense of pride of their nation. Kennedy says, â€Å"For I have sworn before you and Almighty God the same solemn oath our forebears prescribed nearly a century and three-quarters ago† (Kennedy). One reason that makes Kennedy revisit ancient achievements is to show that he is in line with American Vision and to build a good name for himself. To Americans, the day when they have received their independence means very much – it is one of the most significant moments in their history. Mentioning it, Kennedy is bound to get some followers who associate themselves with the independence. He later claims, â€Å"Let the word go forth from this time and place, to friend and foe alike, that the torch has been passed to a new generation of Americans born in this century, tempered by war, disciplined by a hard and bitter peace, proud of our ancient heritage † (Kennedy). By this, Kennedy shows, through words, a picture to the Americans – he has taken the mantle from leaders before him to fulfill certain tasks and responsibilities according to the collective wish of the Americans. Secondly, JFK seeks support for his presidency and uses the unification tool to lure Americans to support him. His speech is full of anaphora of â€Å"to† and â€Å"let both sides† to address both the republicans and the democrats present in this inauguration. JFK has a goal of uniting all Americans and fighting racism. To achieve this, he sates, â€Å"And so, my fellow Americans: ask not what your country can do for you—ask what you can do for your country. My fellow citizens of the world: ask not what America will do for you, but what together we can do for the freedom of man† (Kennedy). This statement inspires Americans and the world at large as they have so much they can do for their country. Additionally, it demonstrates them that if people collectively put their mind to something, they will achieve it. For instance, it will take unification to do away with racism, corruption, and achieve world freedom and world peace. Additionally, Kennedy unifies the public through the use of alliteration. For instance, he says, â€Å"Let’s go forth and lead the land we love†

Importance of Marketing for Organization Success Essay

Importance of Marketing for Organization Success - Essay Example ys marketing concept is implied in the idea, that marketing decisions must be made taking into account the needs of the customers in the first place and afterwards the process of developing and marketing services and products should be initiated by an organization (Nickels, 2008). The major aim of marketing efforts of any organization is to establish reliable relationships with clients that are to be beneficial both for the clients and the organization. And every effort is to prove the fact that marketing plays a crucial role for the business of any size and the society as well. Talking about marketing as a necessary business function it is vital at organizational level for non-for-profit and for-profit businesses engaged in all the industries (Nickels, 2008). As far as non-for-profit organizations are concerned marketing is to assist in process of attracting clients in order to maintain the mission of the organization which might be support or donations raise. For-profit organizations need marketing to deal with all the tasks meant to bring revenue and profits to organization. These two types of organizations will not be able to survive without a helping hand of marketing tool. The feature of marketing as the area of organizational business is implied in the interaction with the public and the opinion that is formed about the organization is the result of interaction with marketers. And thanks to advertising message a customer may believe that this or that company is creative and dynamic (Nickels, 2008). The primary role of marketers is to establish specific relationships intended for holding value for both organization and customers, in this respect marketing professionals apply a diverse toolkit which is to serve as a spine of decision making process. The toolkit includes: Each element in the toolkit is in tight connection and interaction with each other and as a result decisions made in one area are influential for those decisions made in other areas. For

San Francisco Peaks Research Paper Example | Topics and Well Written Essays - 1000 words

San Francisco Peaks - Research Paper Example However this entire mystery was resolved in 1980 when Mount St. Helen’s erupted. It is because of this erosion that the scientists and geologists were able to figure out that due to volcanoes a mountains entire face can disappear. Further, with the help of the geological testing and aerial photos it was concluded that the San Francisco Peaks experience the same kind of erosion and that is why it took a unique formation. It is believed by the geologists that the actual peaks were more than 16,000 feet high (San Francisco Peaks) The Peaks The San Francisco Peaks are located to the north of Flagstaff, Arizona and has a height of about 12,633 feet. It is considered to be the most distinct geological mark of the Colorado Plateau. These peaks have been named after the settler in the region the early 1620s named St. Francis of Assisi, however in the local area these are referred to as Peaks. The peaks are a collective formation of six summits that encircle the volcanic crater, which is now a quiet volcano. Out of all the six, the highest peak in Arizona is Humphreys Peak that is 12,633 feet high, Agassiz Peak is about 12,356 feet and the Fremont Peak soars up to 11,969 feet. The remaining three peaks; Aubineau Peak, Reese Peak and the Doyle Peak climb up to 11,838 feet, 11,474 feet and 11,460 feet respectively. Together all these peaks make a circular ring making the peaks the most significant geological display of volcanic rocks, together with the picturesque view of the lava flows and the deep alpine forest. As the peaks are a unique formation, they provide a dramatic landscape of the Flagstaff that is isolated, huge and quite unexpected. Since the peaks are quite tower-like, these can be viewed from quite a distance even from the Wupatki National Monuments (Priest, Duffield and Malis-Clark). Today these peaks have become tourist attractions as millions of people visit this place every year. The Peaks have a protected alpine environment (Inner Basin), a ski r esort (Arizona Snowbowl) and the Humphreys Peak (the highest point of Arizona). People visit the place for hiking, wildlife viewing, camping, and skiing and wilderness seclusion. The Formation of the Peaks Arizona’s volcanic pleasures begin to form about 6 million years ago when there were 600 volcanic eruptions in the region. It was due to these volcanic eruptions that the Peaks were formed, mainly the Humphrey’s peak that soared above the terrain making it a geological landscape, otherwise it would just have been a dry and arid plateau. Although the history of the formation of the Peaks varies in the region however the general geologic history remains quite the same. Nearly about 500 million years ago the Plateau region was below or at the sea levels and the sediments of limestone began to accumulate underneath. Although most of the volcanic eruptions are near the tectonic plates in the earths crust however Arizona has been quite far from the North American Plate. Th e reason of volcanic eruptions in this region is believed to be the molten rock that is the trapped area beneath the Northern Arizona named as the hot spot. This molten rock occasionally rises, moving the plate to the west and creating volcanoes. The Peaks are believed to be formed nearly 500,000 to 1 million years ago however its inner basin has been quite since its formation (Jones). Many geologists name this formation of the San Francisco Peaks as a stratovolcano meaning that it

Importance of Marketing for Organization Success Essay

Importance of Marketing for Organization Success - Essay Example ys marketing concept is implied in the idea, that marketing decisions must be made taking into account the needs of the customers in the first place and afterwards the process of developing and marketing services and products should be initiated by an organization (Nickels, 2008). The major aim of marketing efforts of any organization is to establish reliable relationships with clients that are to be beneficial both for the clients and the organization. And every effort is to prove the fact that marketing plays a crucial role for the business of any size and the society as well. Talking about marketing as a necessary business function it is vital at organizational level for non-for-profit and for-profit businesses engaged in all the industries (Nickels, 2008). As far as non-for-profit organizations are concerned marketing is to assist in process of attracting clients in order to maintain the mission of the organization which might be support or donations raise. For-profit organizations need marketing to deal with all the tasks meant to bring revenue and profits to organization. These two types of organizations will not be able to survive without a helping hand of marketing tool. The feature of marketing as the area of organizational business is implied in the interaction with the public and the opinion that is formed about the organization is the result of interaction with marketers. And thanks to advertising message a customer may believe that this or that company is creative and dynamic (Nickels, 2008). The primary role of marketers is to establish specific relationships intended for holding value for both organization and customers, in this respect marketing professionals apply a diverse toolkit which is to serve as a spine of decision making process. The toolkit includes: Each element in the toolkit is in tight connection and interaction with each other and as a result decisions made in one area are influential for those decisions made in other areas. For

My dream and where it would take me Essay Example for Free

My dream and where it would take me Essay * Brain Storming: My Dream is a boat I am terribly fond of Write it in the past tense to give the impression of a memory Describe My Dream using personification: red birch, comparison to older lady, adventurous, eager to carve through the water Grandfather was very skilled in this domain, he had a gift Passed on passion for canoeing and I feel certain passion for the sport when he gives me My Dream Setting: Prince Edward Island, grandmothers house, no specific time although indications may show it is set in modern times. Reasons: keeping Nana company because grandfather passed away and I enjoy her company Grandmother is becoming more aged, her wrinkles are deeper, an invisible creature steels her energy and she is forced to stay in bed for long periods of time. She reads to me and as a result I enjoy her company. give background information on ancestors who were Native Americans and so it was necessary that they be able to manipulate a canoe quickly and quietly (surprise attacks) Storm arises, wind is fierce and swells are great. I am very alone and although before I appreciate the solitude, now I am terrified I feel blind, entirely helpless, requires use of new sense: touch and hearing Fog lets up and I am able to sight a protected inlet on shore I avoid the rocks and pull My Dream on to shore I reach land and leave it up to the reader to imagine how I get home, not vital to the topic/plot development I reach home, Nana is not worried, she knew all along that My Dream would bring me safely home * Plan: Introduction: Begin with a walk along the beach while describing some aspects such as sun, sand, wind, ocean etc. Then, I notice My Dream, impatiently waiting for me to let it spread its wings. Expose to the reader my feelings towards canoeing: sense of freedom, isolation from corruption of world, feel the presence of my grandfather. First Paragraph: Mention setting, grandmother (Nanas house) I am keeping her company for the summer because she lives alone on Prince Edward Island. Nana is an intellectual, she reads to me, I develop passion for reading. Second Paragraph: With some technical difficulty, I manage to slide My Dream into the water Describe my grandfathers gift for canoeing When I was younger we spent long afternoons, in the shade of willow trees, with cottages passing us by I would observe him, and he would observe nature (dolphins, eagles, rays, and turtles) We would always come back with an adventure to recount to Nana/parents Third Paragraph: Portray actual moment when passion began to surface Namely, fifteenth birthday, when finally I obtain the canoe I always wanted to be solely mine, My Dream Fourth Paragraph: Discuss in three or four lines the purpose of Native Americans during their attacks by canoe: surprise This required perfect skills that made no sound, a tradition that was continued in my family I begin to paddle, first stroke provokes happy/joyful sentiments No particular direction, wherever the wind chooses to take me, one should never contradict the wind, it is dangerous One must canoe at a safe distance form shore Family of porpoises approach (brings the reader back to theme of calm, beautiful sea, before setting up for storm the calm before the storm) Fifth Paragraph: Storm erupts, terrible wind and downpour, I dont have any extra clothes, pull hood over head for protection. I feel alone, vulnerable Fear of My Dream capsizing Sixth paragraph: I attempt to imagine how my grandfather might feel Put my faith in my boat and in myself, giving up was not in my nature. Seventh paragraph: I thought about my Nana and how worried she would be when she awoke Perhaps she would feel just as alone/scared as I was Eighth paragraph: It was hard to paddle against the strong current, all my work would constantly be undone by the enormous waves Mist lifts a little, I amble to distinguish a protected inlet on the shore line (no rocks) Steer towards it Conclusion: the focus shifts to Nanas house as I am entering She knew that I would come home, only slightly concerned for she understood that I was similar to grandfather and My Dream would bring me home. My Dream The sand, greeted by the rays of the sun, was warm and dry under my bare feet. Drowsily, I sauntered along to the edge of the water. The wind played with my hair and the salty mist of the ocean kissed me gently on the cheek. I was suddenly aware of My Dream. She had lay there all night and seemed restless for the waves teased her as they hit her bow. How I loved to look upon her. My Dream was composed of red birch, a strong, durable, closed-grained wood with a very even, smooth texture. She had the grace of an elderly lady, yet vibrant with life and eager for adventure and company. Her inviting nature made it impossible to resist the temptation to slide inside and paddle away. However, I could not stray too far from my dear Nana. She lived isolated from society on the north shore of Prince Edward Island and I had come from Toronto to offer her my camaraderie for the summer. Since the last time I had visited, I had noticed she had withered and grown grey. She had a fine sense of humour and so I enjoyed my time with her immensely. I adored the evenings where she would open a classical novel and read to me. This ritual had begun before I was able to read and as a result, I had developed a passion for literature. Oliver Twist, Tom Sawyer, David Copperfield, Bilbo and Frodo Baggins became my childhood friends. Then, her time spent awake grew precious. Her cot had asked for her company incessantly and she never refused such demands. Presently, Nana was resting and so would not miss me, but I would have to return shortly. With no little effort My Dream glided smoothly into the sea. She has been in our family for many generations, yet then she was entirely devoted to me. My grandfather had patiently instructed me in canoeing. He had a passion for it. To most people the ability to manipulate a canoe is a skill. This is too delicate a word to describe the way in which my grandfather paddled. He had a gift. When he sat in our canoe, it was as if man and canoe became one. I can recall the many afternoons of solitude and tranquillity as we travelled along in My Dream. I had the honorary position in front of but facing my grandfather. I would study how calmly and skilfully he manoeuvred the canoe in all sorts of seas, and he would study nature. Although he referred to them as mischievous beasts, he loved the hawk that soared defiantly at high altitudes with its magnificent wings spread wide. His eyes would light up at the spotting of a group of Steller sea lions. They would flaunt their nautical capacities and then would vanish into the ocean trailing their hind feet or flippers behind them. We would invariably return home to Nana and to my parents with an adventure or a sighting to recount. My grandfather had passed his passion for canoeing to me. I am most content when I am nestled in my canoe, gliding through water. Yet, I am not able to precisely pinpoint when this ardour had begun to surface. Surely, it was when my grandfather presented me with My Dream on my fifteenth birthday. He had sanded and polished her and her name had been repainted in gold letters. Rays of sunlight caused her to take on a youthful appearance. My ancestors were Native Indian and in order to triumph in times of war, they planned surprise attacks arriving by canoe. Their rhythmic strokes were at one with the water as they urged the young warriors onward towards their quest. One could only have heard their breathing. Our family has continued to practice such faultless paddling. I placed one of the long, aged paddles, which had been My Dreams comrade since her beginning, across the gunnels. I slid into the boat with ease. I did not have a chosen course, I would follow the wind. Many people endeavour to challenge the wind, but its dominating character will not tolerate such provocative behaviour. My first stroke was strong, steady and instantly I was euphoric. There was a certain distance one could travel from shore after which the swells were too large for My Dream to navigate safely. After I had reached this distance, I stopped paddling and lay in the abdomen of my guardian. I knew that the oceanic waves would quickly cause My Dream to drift into shore. A family of porpoises playfully approached. I had seen them only just last week. They had grown and soon they would venture off to satisfy their curiosity with the wonders of the ocean, whose manner, they would soon discover, was unruly. Something wet brushed against my cheek. I paid no heed, until yet another splash landed on my forehead. I sat up quickly. A dark, ominous cloud had cast a shadow on My Dream. It had begun to rain and there was no visible land in sight. The waves whipped against the side of the canoe and the spray of the salt water stung my eyes. A fog enveloped My Dream and with a shock, I realized I had forgotten my compass. The wind changed direction numerous times. I was forced to adjust the direction of the canoe to avoid being capsized by the strong wind and high waves. I was entirely dependant on my sense of hearing and touch. I imagined this was similar to being blind. I had always loved to canoe because it offered isolation from the pressures of life. Now, alone, I was terrified. The ocean was quick to anger when a storm came to torment it. I pulled my hood over my head and hoped that this would keep my head dry. I could hear the downpour on the water and on My Dream. The sound was terribly loud and consequently I couldnt think of anything else. I tried to consider how my grandfather would have reacted if he were here. He had been an excellent judge of weather, and probably would not have gone out at all on that day. My canoe lost all dignity as she was tossed about recklessly. We are here together, and I will never abandon you, I shouted to My Dream, who was showing every indication of being just as nervous and agitated as I was. I trust you, I whispered because I understood that the only way I was going to survive was if I had faith in My Dream and in myself. Suddenly, I had a vision of my Nana, sitting in her rocking chair, balancing back and forth gazing searchingly out of the window of the front parlour. Her face was melancholy and a tear paused a moment before streaming down her cheek. I supposed that she had felt lost and alone, just as I had in that storm. However, her cause was worthier for she had been frightened for me and selfishly, I had been frightened for myself. The current was strong, and trying to paddle against it was laborious and strenuous work. Each time I advanced by a few feet, an enormous wave would undo all my progression. I wanted to cry but I did not have the energy and no one would have heard over the tumult of the storm. My spirits had fallen, I was wet, cold and thirsty. I looked down and a flash of lightening revealed my callous hands. I had hardly noticed that the heavy mist had slightly lifted, and although the torrent continued, the thunder had ceased. The shoreline was hazy, but I could make out a protected inlet. It was not safe to approach the shore anywhere else because it was rocky and would certainly destroy My Dream. I navigated towards it. The waves, having had their fun, let me pass with little trouble. Before My Dream collided with land, I jumped out and pulled her safely on to the sand. Is that you? my grandmother asked as I gently closed the door behind me. I had expected her voice to be shaken and high pitched, as it had been when my grandfather had moved to Heaven. However, her voice was calm. I wondered why she was not concerned. Afterward, she explained that I was comparable with my grandfather in many respects. She had known that I would carve my way through the rough waters and that My Dream would deliver me unharmed to land. Yes, it is I Nana. I answered.

What Is Angelman Syndrome Biology Essay

What Is Angelman Syndrome Biology Essay Parents: What is Angelman Syndrome? Me: Angelman syndrome is a nervous disorder of the brain also called as Puppet syndrome. The syndrome was first reported by a British pediatrician Dr. Harry Angelman in 1965. It leads to mental disorder accompanied with speech problems. This is a very rare condition that sometimes even doctors are not completely aware of it. The syndrome is often misdiagnosed with cerebral palsy, autism or other mental disorders of children. The occurrence is approximately 1 in 25,000. Parents: What is the Prognosis of the syndrome? Me: The individuals with this condition have quite a healthy and normal life span. Some of the common features that can be noted are sleeping disorders, attention deficiency, speech problems and hyperactivity. Even these can slowly diminish with age. Their sexual development is normal. Puberty and menstrual cycle are also normal and occur at the right approximate age. There are high risks of having severe developmental delays which can be minimized or avoided to an extent by early diagnosis and therapy. They can lead an independent adult life except people who also have epilepsy along with this syndrome. Parents: We found her being slightly abnormal, she wasnt able to grasp what we are telling and is really struggling to pronounce words. What are the other possible symptoms? Me: The main symptoms of the disease are mental retardation, speech problems and hyperactive behavior. It is usually present right from birth but the symptoms of it are mostly not noticed until the age of 3. But certain developmental delays can be noted between 6 to 12 months of the child. Usually their MRI and CT scan reports show structurally normal brain features. They may have no speech or very low speaking capacity. They have higher tendency in actions rather than verbal communication. They show some unique behavior like hand flapping, attention deficiency, frequent laughter, sleeping disturbances, delayed toilet training, feeding problems and easily excitable personality. Seizures are noted only after the age of three so the possibility of identifying the syndrome before this age is not always possible. Their Electroencephalography (EEG) reports turn out to be abnormal; EEG is a test used to check the neural activity of the brain. They have much attraction to water and are highly sensitive to heat. It is not completely known why laughter is so frequent in this syndrome. Continuous smiling, abnormal facial gestures followed by burst of laughter in public are noted in almost 70 75% of the cases. They may not have good balancing capacity to walk. Trembling legs are noted along with ataxia. Ataxia is a condition where there is no co-ordination of muscular movements. They have trembling feet resulting is disability to walk. Normal sitting and walking may take 3-4 yrs of age. In highly severe cases walking is not possible until they are older, or it may be robotic. 100% of the cases are mentally retarded with attention deficit and which is non-progressive. They may be severe in most of the cases. Mostly they would need a sheltered life in their adulthood. Parents: Oh! Do they show any abnormal physical features? Because our daughter seems to look quite normal. Me: Yes! They do. Some of the common ones are a flat head at the back, wide opened mouth with spaced teeth, light hair and eye color, deep set eyes, excessive chewing behaviors, lightly pigmented skin texture, uplifted arm position, enlarged toes, soft and tender palms, tongue thrusting, and frequent drooling. A small head may be found in certain cases. All the symptoms which I have said both physical and clinical need not necessarily be found in all kids with this syndrome. They may occur in different combinations and in different levels. Parents: How did the condition arise? Me: Angelman syndrome occurs due to the deletion of a part of the chromosome 15 known as 15q11-13 that comes from the mother which results in abnormal or no expression of the maternal chromosome in the child. And hence all the functions of the chromosome 15 are being affected. Around 60-65% patients are affected by this cause. In 2-5% of the cases there may be two copies of chromosome 15 from the father and no chromosome from the mother. This condition is termed as uniparental disomy. Sometimes the chromosome obtained from the mother functions exactly the same as the chromosome obtained from the father. Rarely AS may result due to breaks in the chromosome like translocation where two chromosomes break and exchange their broken pieces. The other type is inversion where a chromosome breaks and gets attached in the opposite direction. In both these cases the exact combination of amino acids is changed which would affect the production of ubiquitin ligase protein. And finally in 20% cases there may be a fault in the UBE3A gene which is present on chromosome 15. UBE3A is ubiquitin ligase, which is considered as one of the major factors for the normal development and functioning of the brain. The relevancy of this gene to the disease is not yet completely known. 15-20% of the cases are unidentified mutation. They are still under study and a clear cause is not defined. Parents: What is the importance of these chromosomes? Me: Every chromosome is made of DNA which consists of specific amino acids. Different combinations of amino acids help in producing different proteins which are responsible for specific functions in the body. So when there is an alteration in the chromosome it affects the production of the particular protein. So automatically the protein function is lost and the relevant disorder arises. The protein that is involved in brain growth and function is called as ubiquitin ligase protein which is produced from the chromosome 15 of the mother. The condition is always from the chromosome 15 of the mother. The same chromosome from the father is also equally important but alterations in the fathers gene would lead to a different condition called the Prader Willi Syndrome. Parents: What are the ways of diagnosis? Me: Diagnosing AS is difficult during infancy. The criteria for diagnosis was developed only in 1995 and further revised in 2000 by the Angelman syndrome society (USA). In certain cases parents or doctors may find developmental delays between 6-12 months of the child. Even all brain scan reports turn to be quite normal. Only after the age of two or three notable changes can be found like concentration problems, speech impairment, balance disorder, frequent smiling or flapping of hands. After the age of three EEG reports can be found abnormal which is be followed by DNA analysis. Sometimes even genetic reports turn out to be normal which can lead to a lot of confusion and misdiagnosis. Family history of the syndrome and development history of the child is completely studied and genetic expression of the ubiquitin protein is confirmed. The confirmatory test for the Angelman Syndrome involves testing of blood in four steps: The size, shape and number of chromosomes in a cell sample are noted for changes. This is known as karyotyping. Genetic analysis to find missing chromosomes. This is done by a specialized process called FISH (fluorescent in-situ hybridization). A test called DNA methylation test is done where the result will confirm whether the DNA of both the parents is expressed. If both the DNA copies are expressed it means that they are active. In cases of AS only paternal or the fathers DNA is expressed. Finally UBE3A protein is sequenced. This is done because sometimes DNA methylation test turns to be normal. This is due to the condition that maternal DNA is normally expressed but mutated. Parents: Is Gene therapy possible. What are the other possible treatment methods? Me: There is no possible treatment for the disease at the genetic level. Since 99% of the cases are spontaneous mutation the possibility of prevention is also at the least level. Angelman syndrome is a collection of various medical conditions; hence separate therapies can be carried out for every symptom to provide a better lifestyle for the patient. The therapies are selected according to the noted symptoms and their level of effect on the individual. From the age of 3 speech and communication therapy is recommended for improving their speaking and communicating skills. Occupational therapy is carried out for everyday living skills. Physiotherapy can help in better walking and other motor activities. Sometimes hypermotoric behaviors cant be controlled by behavioral therapy so perfectly safe environment must be provided. If the condition is accompanied by epilepsy, separate medications are followed as prescribed by the physician for treatment of seizures. Medications are also available for sleeping problems, hyperactivity etc. Non prescribed sedatives are not to be given because they may lead to negative side effects. Because that they have feeding problems their nutritional status should be frequently monitored. Surgeries are available for conditions like strabismus and other orthopedic problems. Surgical rod stabilization is done for severe curvatures. During old age the individuals become less mobile and are not much active. They must be given scheduled work under supervision to avoid obesity and scoliosis. Scoliosis is a condition of severe curvature side to side in the spinal cord. Parents: What is the mode of inheritance? Will our future children be affected? The risk of inheritance is based upon the type of mutation that occurs in the parents. With no family history for the disease and if the occurrence is completely spontaneous during cell division then the chances of getting the disorder in consequent children is